Factrel 20ml
Factrel Injection is a sterile solution containing 50 micrograms of synthetic gonadorelin (as hydrochloride) per mL in aqueous formulation containing 0.6% sodium chloride and 2% benzyl alcohol (as a preservative). Gonadorelin is the gonadotropin releasing hormone (GnRH) which is produced by the hypothalamus and causes the release of the gonadotropin luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary.
FACTREL Injection has the identical amino acid sequence as endogenous gonadorelin; 5-oxo Pro-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2 with identical physiological activities. The molecular weight of gonadorelin is 1182 with a molecular formula of C55H75N17O13.
The corresponding values for gonadorelin hydrochloride are 1219 (1 HCI) expressed as C55H75N17O13HCI, or 1255 (2 HCI) expressed as C55H75N17O13 2HCI. Potenay Gold B12
Factrel Indications For Use
For the treatment of ovarian follicular cysts in lactating dairy cows, beef cows, and replacement dairy and beef heifers. The treatment effect of FACTREL 20ml Injection when used in lactating dairy cows, beef cows, and replacement dairy and beef heifers is a reduction in the number of days to first estrus.
For use with LUTALYSE (dinoprost tromethamine injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows.
Factrel Dosage & Administration:
For the treatment of ovarian follicular cysts in lactating dairy cows, beef cows, and replacement dairy and beef heifers: Administer 2 mL of FACTREL Injection as a single intramuscular injection.
For use with LUTALYSE (dinoprost tromethamine injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 to 4 mL FACTREL Injection (100-200 mcg
gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework:
- • Administer the first dose of FACTREL Injection (2-4 mL) at Day 0
- • Administer LUTALYSE (25 mg dinoprost, as dinoprost tromethamine injection) Injection by intramuscular injection 6-8 days after the first dose of FACTREL Injection.
- • Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE injection.
- • Perform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices.
Below are three examples of treatment regimens for FTAI that fit within the dosage
regimen framework described immediately above:
Below are three examples of treatment regimens for FTAI with FACTREL and LUTALYSE. Ketaset 10ml
|
Example 1 |
Example 2 |
Example 3 |
| Day 0 (Monday) |
1st FACTREL |
1st FACTREL |
1st FACTREL |
| Day 7 (the following Monday) |
LUTALYSE |
LUTALYSE |
LUTALYSE |
| Day 9 (Wednesday) |
2nd FACTREL + FTAI at 48 hours after LUTALYSE |
2nd FACTREL 48 hours after LUTALYSE |
2nd FACTREL 56 hours after LUTALYSE |
| Day 10 (Thursday) |
|
FTAI 24 hours after 2nd FACTREL |
FTAI 16 hours after FACTREL |
The recommended dosage of FACTREL for the treatment of ovarian follicular cysts in cattle is 2 mL/cow intramuscularly.
Ingredients:
Each ml of Factrel Injectable solution contains 50 micrograms of synthetic gonadorelin (as hydrochloride) in aqueous formulation containing 0.6% sodium chloride and 2% benzyl alcohol (as a preservative).
Storage
Store Factrel 20ml at refrigerator temperature 2° to 8°C (36° to 46°F).
Factrel Packaging
FACTREL Injection is available in a
20ml vial (10 doses)
50mL vial (25 doses)
Caution
Because Factrel injectable solution is identical to endogenous GnRH such that both are rapidly metabolized without detectable levels in milk or tissue, no withdrawal period is required.
Shipping
Ships on ice overnight
Flunidin 100ml
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