Zactran contains gamithromycin, a macrolide sub-class antimicrobial. For treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis, and for control of BRD associated with Mannheimia haemolytica and Pasteurella multocida in beef and non-lactating dairy cattle. A single dose of Zactran provides up to 10 days BRD treatment and control. Administer one dose, 2 ml per 110 lbs. SQ in the neck, not to exceed 10 ml per injection site. Zactran is not for use in female dairy cattle 20 months of age or older, or in calves to be processed for veal. Gamithromycin 150 mg/ml.
Zactran Injection for Cattle is a ready to use sterile parenteral solution containing gamithromycin, a macrolide sub-class, 7a-azalide antimicrobial. Each mL of Zactran contains 150 mg of gamithromycin
as the free base, 1 mg of monothioglycerol and 40 mg of succinica cid in
aglycerol formal vehicle.
The chemical name of gamithromycin is 1-Oxa-7-azacyclopentadecan15-one,13-[(2,6-
dideoy-3-C-methyl3-O-methyl-alpha-Lribo-hexopyranosyl)
oxy]-2-ethyl-3,4,10-
trihydroxy 3,5,8,10,12,14-
hexamethyl-7-propyl11-{[3,4,6-trideoxy-3-
(dimethylamino)-beta-Dxylo-hexopyranosyl]oxy}-,
[(2R*, 3S*,4R*,5S*,8R*,
10R*,11R*,12S*,13S*,1
4R*)]-and the structure
is shown below.
INDICATIONS
ZACTRAN is indicated for the treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis in beef and non-lactating dairy
cattle.
ZACTRAN is also indicated for the control of respiratory disease in beef and non-lactating dairy cattle at high risk of developing BRD associated with Mannheimia haemolytica and Pasteurella multocida.
DOSAGE and ADMINISTRATION
Administer ZACTRAN one time as a subcutaneous injection in the neck at 6 mg/kg (2 mL/110 lb) body weight (BW). If the total dose exceeds 10 mL, divide the dose so that no more than 10 mL is administered at
each injection site.
Animals should be appropriately restrained to achieve the proper route of administration. Use sterile equipment. Inject under the skin in front of the shoulder (see illustration).
CONTRAINDICATIONS
As with all drugs, the use of ZACTRAN is contraindicated in animals previously found to be hypersensitive to this drug.
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