Best Anti-inflammatory for horses includes Anecdotally,  phenylbutazone is thought to be more effective and preferred by equine practitioners for reducing inflammation and lameness due to orthopedic disorders.
Non-steroidal anti-inflammatory drugs (NSAIDs) are probably some of the most widely used drugs used in both human and equine medicine. They act to reduce pain by inhibiting the inflammatory pathways after injury. Common NSAIDs used in human medicine include aspirin, paracetamol and ibuprofen.
NSAIDs used in equine medicine include phenylbutazone (bute), meloxicam, suxibuzone and flunixin. NSAIDs may be administered by injection, orally (as a powder, granules or paste given in feed or by mouth) or in a cream, ointment, gel or lotion to apply to the surface of
inflamed tissues such as the skin.
NSAIDs are a benefit to the welfare of the equine population through the control of pain and inflammation.
The term ‘non-steroidal’ is used to distinguish these drugs from steroid anti-inflammatories (cortisone). They act by inhibiting a class of enzymes called cyclooxygenase (COX). COX enzymes are involved
in the inflammatory process which is responsible for
inflammation, pain and fever.

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